4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
CAS: 84955-31-7
Molecular Formula: C6H5ClN4
4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine - Names and Identifiers
| Name | 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine |
| Synonyms | 6-CHLORO-7-DEAZAGUANINE 6-Chloro-7-deazaguanine 2-amino-6-chloro-7-deazapurine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE 2-Amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine 4-CHLORO-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-2-YLAMINE |
| CAS | 84955-31-7 |
| EINECS | 640-149-4 |
| InChI | InChI=1/C6H5ClN4/c7-4-3-1-2-9-5(3)11-6(8)10-4/h1-2H,(H3,8,9,10,11) |
| InChIKey | VIVLSUIQHWGALQ-UHFFFAOYSA-N |
4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine - Physico-chemical Properties
| Molecular Formula | C6H5ClN4 |
| Molar Mass | 168.58 |
| Density | 1.82±0.1 g/cm3(Predicted) |
| Melting Point | 215-217°C |
| Boling Point | 346.6±52.0 °C(Predicted) |
| Flash Point | 239.4°C |
| Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| Vapor Presure | 4.33E-09mmHg at 25°C |
| Appearance | Powder |
| Color | Pale yellow to yellow |
| pKa | 10.68±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.8 |
4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine - Reference Information
| Application | 2-amino-4-chloropyrrolo [2,3-D] pyrimidine is, commonly used intermediates in chemical preparation. Pyrrole [2,3-d] Pyrimidine compound is an important drug intermediate. This kind of compound not only has unique curative effect in analgesic and anticancer, but also can treat rheumatoid arthritis, psoriasis, diabetes and other incurable diseases, it is a drug intermediate with wide application prospect. Therefore, the synthesis of these compounds has attracted much attention in recent years. |
| preparation | at present, there are three main methods for the synthesis of pyrrole [2,3-d] pyrimidine compounds: the pyrrole ring was constructed with pyrimidine compound as substrate, the pyrimidine ring was constructed with pyrrole as parent, and the two heterocycles were constructed simultaneously. Synthesis of 2-amino-4-chloropyrrolo [2,3-D] Pyrimidine with 2, 6-diamino-6-hydroxypyrimidine as starting material, it is prepared by cyclization, reduction and chlorination, the synthetic route map is as follows: Fig. 1 route map for the synthesis of 2-amino-4-chloropyrrolo [2,3-D] pyrimidine |
Last Update：2024-04-09 02:00:12
![4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine](http://res.chembk.com/assets/str/2d/8/84/84955-31-7.png)
Supplier List
Spot supply
Product Name: 2-Amino-4-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine Visit Supplier Webpage Request for quotationCAS: 84955-31-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: 2-Amino-4-Chloro-7H-Pyrrolo[2,3-d]Pyrimidine Visit Supplier Webpage Request for quotationCAS: 84955-31-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History